![]() Liquid bandage formulations are potentially well placed to redress these limitations, being facile to apply and intrinsically amenable to modification for added functionality or fine-tuning. ![]() The principal drawbacks of conventional bandages are (1) the inconvenient and/or labour-intensive application that is required (2) the requirement for regular changing, to avoid them becoming niduses for infection and (3) the requirement for antimicrobial under-dressings. Similar content being viewed by othersīandaging is an enduring approach to the medical and surgical management of wounds, with a myriad of benefits including, provision of structural support, prevention of ingress of dirt and infectious microbes from the environment, and the securing of dressings and topical therapeutics (e.g. This new class of bandage has promise for challenging topical situations in humans and other animals, especially away from controlled, sterile clinical settings where wounds urgently require protection from environmental and bacterial contamination. Treatment was well-tolerated and clinical improvement was observed in animal mobility. The bandage self-degraded, appropriately, over 7 days despite extreme conditions (faecal slurry). When challenged in vivo with the polybacterial bovine wound infection ‘digital dermatitis’, Zn/Cu-shellac adhered rapidly and robustly over pre-applied antibiotic. ![]() The material demonstrated marked antibacterial contact properties and, in ex-vivo studies, effectively locked-in pre-applied therapeutics. We show here that antibacterial zinc (Zn) and copper (Cu) species greatly enhance the barrier properties of the natural, waterproof, bio-adhesive polymer, shellac. Rapid-set liquid bandages are efficient alternatives but lack durability or inherent infection control. Bandages must be changed and infection risk managed. Bandaging is a steadfast but time-consuming component of wound care with limited technical advancements to date.
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